MilliporeSigma Calbiochem Dexamethasone
Most active and highly stable glucocorticoid.
Manufacturer: MilliporeSigma 265005100MG
DescriptionMost active and highly stable glucocorticoid. Causes a reduction in cyclin A and Cdk2 activity, and inhibition of G1/S transition in osteoblasts. Inhibits the phosphorylation of retinoblastoma (Rb) protein. Inhibits the expression of inducible but not constitutive nitric oxide synthase in vascular endothelial cells (IC50 = 5 nM). Enhances active cation transport in aortic smooth muscle cells by stimulating the Na+ - K+ pump. Induces apoptosis in human thymocytes.
|99% by TLC|
|Phosphorylation of rb protein|
|DMSO, CHCl3 or EtOH|
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