MilliporeSigma™ Calbiochem™ DMBO

Catalog No.	Quantity
31-720-110MG	10 mg

Catalog No. 31-720-110MG Supplier MilliporeSigma™ Supplier No. 31720110MG

Description

An oxazine that appears to mimic the pyranosidic moiety of heparin sulfate, and is shown to interact directly with several growth factors and cytokines including VEGF, TNF-α and heparin-binding-EGF in a surface plasmon resonance assay.

An oxazine that appears to mimic the pyranosidic moiety of heparin sulfate, and is shown to interact directly with several growth factors and cytokines including VEGF, TNF-α and heparin-binding-EGF in a surface plasmon resonance assay. At concentrations of 10-80μM, this compound dose-dependently inhibits the proliferation of VEGF-expressing LM8G7 cells (IC₅₀ = 13μM), and TNF-α-expressing OVSAHO cells (IC₅₀ = 19μM). At 195μM, a 99% reduction in cell growth is observed in HB-EGF-expressing SKOV-3 cultures. This compound inhibits heparanase-mediated degradation of heparin sulfate in LM8G7 cells (IC₅₀ = 65μM and 104-206μM, in an enzymatic and a cell based assay, respectively). At 0.5-5μM, it markedly prevents the migration and invasion of the same culture, in a dose-dependent manner. In addition, it completely suppresses liver metastatic nodules of osteosarcoma mice injected with LM8G7 cells at 0.5mg/kg without any signs of toxicity in vivo , and demonstrates a synergistic anti-tumor effect when dosed with heparin.

Specifications

• Color: White
• Description: 95% by HPLC
• Molecular Formula: C₂₂H₂₅F₂NO₂
• Formula Weight: 373.4g/mol
• Solubility: DMSO
• Content And Storage: Protect from light
• Form: Solid
• Quantity: 10 mg