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MilliporeSigma™ Calbiochem™ Dynamin Inhibitor III, Phthaladyn-23

Catalog No. 32441210MG Shop All MilliporeSigma Products
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32-441-210MG 10 mg
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Description

A cell-permeable phthalimide compound that is reported to inhibit dynamin GTPase activity (IC50 =

A cell-permeable phthalimide compound that is reported to inhibit dynamin GTPase activity (IC50 = 17.4 and 63μM using purified sheep brain dynamin I and recombinant dynamin II, respectively) in a GTP-competitive manner. Shown to block K+-induced SVE (synaptic vesicle endocytosis) of FM4-64 dye into rat brain synaptosomes (IC50 = 12.9μM), while being ineffective at 30μM against RME (receptor-mediated endocytosis) of transferrin into human osteosarcoma epithelial U2OS cells, presumably due to poor dynamin II inhibitory potency and/or rapid efflux and/or limited permeability in this cell line.
TRUSTED_SUSTAINABILITY

Specifications

Color Light Yellow to Beige
Description 97% by HPLC
Molecular Formula C22H12ClN3O7
Formula Weight 465.8g/mol
Solubility DMSO
Content And Storage Protect from light
Form Solid
Quantity 10 mg
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