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MilliporeSigma™ Calbiochem™ ERO1 Inhibitor II, EN460

Catalog No. 32850125MG Shop All MilliporeSigma Products
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32-850-125MG 25 mg
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Description

A cell-permeable thiol reactive enone (EN) compound that selectively interacts with the active-site cysteine of reduced, active form of ERO1α and inhibits its activity (IC50

A cell-permeable thiol reactive enone (EN) compound that selectively interacts with the active-site cysteine of reduced, active form of ERO1α and inhibits its activity (IC50 = 1.9μM). Also prevents ERO1 re-oxidation both in vitro and in mouse embryonic fibroblasts. Activates the unfolded protein response and protects ER-stressed 293T cells. Can inhibit ERO1α even in the presence of an excess amount of competing thiols. Can inhibit ERO1α even in the presence of an excess amount of competing thiols. EN460 binding to ERO1α is shown to promote the loss of flavin adenine dinucleotide (FAD) from the holoenzyme. Its inhibitory action appears to be irreversible, however addition of FAD and tris(hydroxypropyl)phosphine (Cat. No. 598250) can restore some enzyme activity.
TRUSTED_SUSTAINABILITY

Specifications

Color Red
Description 99% by HPLC
Molecular Formula C22H12ClF3N2O4
Formula Weight 460.8g/mol
Solubility DMSO
Content And Storage Protect from light
Form Solid
Quantity 25 mg
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