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MilliporeSigma™ Calbiochem™ Eya2 Phosphatase Inhibitor, MLS000544460

Catalog No. 5310850001 Shop All MilliporeSigma Products
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Quantity:
25 mg

Description

A cell-permeable furylidenebenzohydrazide compound that acts as an inhibitor of Eya2 ED tyrosine phosphatase (IC50

A cell-permeable furylidenebenzohydrazide compound that acts as an inhibitor of Eya2 ED tyrosine phosphatase (IC50 = 4.1μM; KD = 2.0μM for hEya2, catalytic domain at 5μM Mg2+). Inhibition appears to be reversible and allosteric in nature. Does not affect the activity of Eya3, PTP1B, PPM1A, and Scp1 even at higher concentration (IC50 > 100μM). Although its binding to Eya2 ED is not Mg2+ dependent, its inhibitory activity is dependent on the concentration of Mg2+ in the medium. At higher Mg2+ levels (∽5 mM) the inhibition is non-competitive whereas at low Mg2+ levels (∽5μM) it has a mixed type inhibition. Reduces Eya2-mediated cell migration in MCF10A cells (∽ 10μM).

Please note that the molecular weight for this compound is batch-specific due to variable water content.
TRUSTED_SUSTAINABILITY

Specifications

Color Beige
Description 97% by HPLC
Target Proteins Eya2 C-terminal Eya domain (ED) protein tyrosine phosphatase
Molecular Formula C17H12FN3O2S
Solubility DMSO
Content And Storage Protect from light
Form Solid
Quantity 25 mg
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