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MilliporeSigma™ Calbiochem™ Fbxo3 Inhibitor, BC-1215

Catalog No. 5048430001 Shop All MilliporeSigma Products
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50-484-30001 10 mg
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Catalog No. 50-484-30001 Supplier MilliporeSigma™ Supplier No. 5048430001
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Description

A cell-permeable, bis-pyridinylbenzylethanamine that disrupts Fbxo3-Fbxl2 interaction and effectively prevents SCF-Fbxo3-catalyzed Fbxl2 ubiquitination, resulting in cellular Fbxl2 upregulation and thereby SCF-Fbxl2-catalyzed TRAFs (TNF Receptor-Associated Factors) ubiquitination

A cell-permeable, bis-pyridinylbenzylethanamine that disrupts Fbxo3-Fbxl2 interaction and effectively prevents SCF-Fbxo3-catalyzed Fbxl2 ubiquitination, resulting in cellular Fbxl2 upregulation and thereby SCF-Fbxl2-catalyzed TRAFs (TNF Receptor-Associated Factors) ubiquitination. Effectively reduces cellular TRAFs (5 to 127μM) and prevents TRAF-mediated cytokines production from LPS-stimulated human PBMC (25μM). Shown to greatly prevent Cecal Ligation & Puncture-induced plasma cytokine elevation and substantially reduce the severity of lung inflammation post intratracheal P. aeruginosa infection in mice (100μg/mouse; i.p.) in vivo .
TRUSTED_SUSTAINABILITY

Specifications

Color Beige
Description 98% by HPLC
Target Proteins Fbox3
Molecular Formula C26H26N4
Solubility DMSO
Content And Storage Protect from light
Form Solid
Quantity 10 mg
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