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MilliporeSigma™ Calbiochem™ Fbxo3 Inhibitor, BC-1215

A cell-permeable, bis-pyridinylbenzylethanamine that disrupts Fbxo3-Fbxl2 interaction and effectively prevents SCF-Fbxo3-catalyzed Fbxl2 ubiquitination, resulting in cellular Fbxl2 upregulation and thereby SCF-Fbxl2-catalyzed TRAFs (TNF Receptor-Associated Factors) ubiquitination

Manufacturer:  MilliporeSigma™ 5.04843.0001

Catalog No. 50-484-30001


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Description

Description

A cell-permeable, bis-pyridinylbenzylethanamine that disrupts Fbxo3-Fbxl2 interaction and effectively prevents SCF-Fbxo3-catalyzed Fbxl2 ubiquitination, resulting in cellular Fbxl2 upregulation and thereby SCF-Fbxl2-catalyzed TRAFs (TNF Receptor-Associated Factors) ubiquitination. Effectively reduces cellular TRAFs (5 to 127µM) and prevents TRAF-mediated cytokines production from LPS-stimulated human PBMC (25µM). Shown to greatly prevent Cecal Ligation & Puncture-induced plasma cytokine elevation and substantially reduce the severity of lung inflammation post intratracheal P. aeruginosa infection in mice (100µg/mouse; i.p.) in vivo .
Specifications

Specifications

98% by HPLC
Protect from Light
Fbox3
DMSO
Beige solid
10mg
C26H26N4
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