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  6. 3425005MG

MilliporeSigma™ Calbiochem™ FK-506, Streptomyces sp.

Catalog No. 3425005MG Shop All MilliporeSigma Products
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Quantity:
5 mg

Description

Immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2.

Immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca2+ release. Inhibits the Ca2+-dependent phosphatase, Protein Phosphatase 2B (Calcineurin; Cat. No. 539568), as well as Na+,K+-ATPase in nephron segments. Also shown to inhibit aldosterone-induced synthesis of Giα-3 protein.
TRUSTED_SUSTAINABILITY

Specifications

Color Off-white
Description 98% by TLC
Target Proteins Immunosuppressant that blocks T cell proliferation
CAS 104987-11-3
Formula Weight 804.1g/mol
Solubility DMSO or MeOH
Content And Storage Protect from moisture
Form Solid
Quantity 5 mg
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