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MilliporeSigma™ Calbiochem™ Focal Adhesion Kinase Inhibitor III

Catalog No. 5040450001 Shop All MilliporeSigma Products
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50-404-50001 10 mg
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Catalog No. 50-404-50001 Supplier MilliporeSigma™ Supplier No. 5040450001
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Description

A cell-permeable pyrazolobenzothiazinedioxide compound that targets and locks FAK in its inactive conformation, resulting in preincubation time-dependent inhibition in kinase assays and FAK autophosphorylation in human prostate cancer PC3M-luc cells (IC50

A cell-permeable pyrazolobenzothiazinedioxide compound that targets and locks FAK in its inactive conformation, resulting in preincubation time-dependent inhibition in kinase assays and FAK autophosphorylation in human prostate cancer PC3M-luc cells (IC50 = 7.1μM with 30 min inhibitor preincubation), while exhibiting little activity toward Akt1, Aurora B, HER2, MEK1, p38α, Pyk2, or Src even at concentrations as high as 10μM.
TRUSTED_SUSTAINABILITY

Specifications

Color Off-white
Description 99% by HPLC
Target Proteins FAK
Molecular Formula C22H26N4O2S
Solubility DMSO
Content And Storage Protect from light
Form Powder
Quantity 10 mg
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