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MilliporeSigma™ Calbiochem™ FtsZ Polymer Stabilizer, PC190723

Catalog No. 3445805MG Shop All MilliporeSigma Products
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34-458-05MG 5 mg
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Description

A benzamide ether derivative that exhibits potent bactericidal activity against Staphylococcus aureus and Bacillus subtilis (minimum inhibitory concentration = 0.5 to 1mg/ml), but does not affect

A benzamide ether derivative that exhibits potent bactericidal activity against Staphylococcus aureus and Bacillus subtilis (minimum inhibitory concentration = 0.5 to 1mg/ml), but does not affect E. coli , yeast, or human hepatocytes. Shown to reduce GTPase activity and induce FtsZ (a prokaryotic homologue of tubulin) polymerization in S. aureus in a dose-dependent manner. Reported to directly inhibit the GTPase activity of FtsZ in a concentration dependent manner (IC50 = 55 ng/ml). Shown to bind between the C-ternimal domain and helix 7 in a region analogous to the Taxol binding site of tubulin. Increases the survival rate to 100% in mice subjected to a lethal dose of S. aureus .
TRUSTED_SUSTAINABILITY

Specifications

Color Tan
Description 97% by HPLC
Target Proteins FtsZ
Molecular Formula C14H8ClF2N3O2S
Formula Weight 355.8g/mol
Solubility DMSO
Content And Storage Protect from light
Form Powder
Quantity 5 mg
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