MilliporeSigma™ Calbiochem™ FtsZ Polymer Stabilizer, PC190723

Description

A benzamide ether derivative that exhibits potent bactericidal activity against Staphylococcus aureus and Bacillus subtilis (minimum inhibitory concentration = 0.5 to 1mg/ml), but does not affect

A benzamide ether derivative that exhibits potent bactericidal activity against Staphylococcus aureus and Bacillus subtilis (minimum inhibitory concentration = 0.5 to 1mg/ml), but does not affect E. coli , yeast, or human hepatocytes. Shown to reduce GTPase activity and induce FtsZ (a prokaryotic homologue of tubulin) polymerization in S. aureus in a dose-dependent manner. Reported to directly inhibit the GTPase activity of FtsZ in a concentration dependent manner (IC₅₀ = 55 ng/ml). Shown to bind between the C-ternimal domain and helix 7 in a region analogous to the Taxol binding site of tubulin. Increases the survival rate to 100% in mice subjected to a lethal dose of S. aureus .

Specifications

• Color: Tan
• Description: 97% by HPLC
• Target Proteins: FtsZ
• Molecular Formula: C₁₄H₈ClF₂N₃O₂S
• Formula Weight: 355.8g/mol
• Solubility: DMSO
• Content And Storage: Protect from light
• Form: Powder
• Quantity: 5 mg