MilliporeSigma™ Calbiochem™ Glucagon-Like Peptide 1 Receptor Agonist II

Catalog No.	Quantity
34-600-710MG	10 mg

Catalog No. 34-600-710MG Supplier MilliporeSigma™ Supplier No. 34600710MG

Description

A pyrimidine small molecule that acts as a GLP-1 allosteric agonist that induces cAMP signaling in HEK293 cells expressing the GLP-1 receptor with EC₅₀

A pyrimidine small molecule that acts as a GLP-1 allosteric agonist that induces cAMP signaling in HEK293 cells expressing the GLP-1 receptor with EC₅₀ = 0.66μM and 99% efficacy (similar data with rat GLP-1 receptor), does not compete with radiolabelled GLP-1 in receptor binding assays, and is not active in cells expressing the GLP-2, GIP, PTH, or glucagon receptors. In rodent islets, insulin secretion increases in a dose-dependent and glucose-dependent manner, either alone or in an additive fashion when combined with the endogenous GLP-1 peptide. In vivo , this molecule exhibits insulinotropic effects when dosed at 10mg/kg in SD rats undergoing an IVGTT and a hyperglycemic clamp. It is also shown to increase insulin secretion in perifusion assays involving normal and diabetic human islets ex vivo , at concentrations between 1 and 10μM.

Specifications

• Color: Off-white
• Description: >95% by HPLC
• Molecular Formula: C₂₀H₁₇F₃N₂O₂S
• Formula Weight: 406.42g/mol
• Solubility: DMSO
• Content And Storage: Protect from light
• Form: Solid
• Quantity: 10 mg