MilliporeSigma™ Calbiochem™ Glucokinase Activator III, Ro-28-1675
A cell-permeable activator of glucokinase. Exhibits in vivo glucose-lowering and insulin-releasing activity
Manufacturer: MilliporeSigma™ 5.09665.0001
DescriptionA cell-permeable thiazolyl-propanamide compound that acts as a glucokinase (GK) activator by increasing Vmax and decreasing [S]1/2 of GK-catalyzed reaction as well as freeing GK from the inhibitory action of GK regulatory protein (GKRP), resulting in increased. Induces GK nuclear-to-cytosol translocation in primary rat hepatocytes and reduces glucose concentration for insulin secretion stimulation from isolated rat pancreatic islets (threshold [glucose] = 3mm vs 6mm with or without 3μM Ro-28-1675). Exhibits in vivo glucose-lowering and insulin-releasing activity in non-diabetic C57BL/6 mice and Wistar rats and is efficacious in several murine and rodent type II diabetes mellitus (T2DM) models (10 to 50mg/kg via p.o.). Does not affect hexokinase I or II activity.
|98% by HPLC|