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MilliporeSigma™ Calbiochem™ Glucokinase Activator III, Ro-28-1675

A cell-permeable activator of glucokinase. Exhibits in vivo glucose-lowering and insulin-releasing activity

Manufacturer:  MilliporeSigma™ 5.09665.0001

Catalog No. 50-966-50001


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Description

Description

A cell-permeable thiazolyl-propanamide compound that acts as a glucokinase (GK) activator by increasing Vmax and decreasing [S]1/2 of GK-catalyzed reaction as well as freeing GK from the inhibitory action of GK regulatory protein (GKRP), resulting in increased. Induces GK nuclear-to-cytosol translocation in primary rat hepatocytes and reduces glucose concentration for insulin secretion stimulation from isolated rat pancreatic islets (threshold [glucose] = 3mm vs 6mm with or without 3μM Ro-28-1675). Exhibits in vivo glucose-lowering and insulin-releasing activity in non-diabetic C57BL/6 mice and Wistar rats and is efficacious in several murine and rodent type II diabetes mellitus (T2DM) models (10 to 50mg/kg via p.o.). Does not affect hexokinase I or II activity.
Specifications

Specifications

10 mg
White
Glucokinase
C18H22N2O3S2
Powder
98% by HPLC
300353-13-3
DMSO
Safety and Handling

Safety and Handling

SDS
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