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MilliporeSigma™ Calbiochem™ GSK-3beta Inhibitor XXVII, CESI

Catalog No. 5057670001 Shop All MilliporeSigma Products
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50-576-70001 10 mg
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Catalog No. 50-576-70001 Supplier MilliporeSigma™ Supplier No. 5.05767.0001

Description

A cell-permeable, 3-hydroxychromone derived compound that acts as a selective and reversible inhibitor of GSK-3β (IC50 < 100

A cell-permeable, 3-hydroxychromone derived compound that acts as a selective and reversible inhibitor of GSK-3β (IC50 < 100nM). Shown to increase phosphorylation at Ser9. Does not show any inhibitory effect on a panel of 15 other protein kinases, including AMPK and Akt. By blocking GSK-3β activity, it acts as a positive regulator of b-catenin signaling. Does not affect the viability or the growth rate of 3T3-L1 preadipocytes, however, it significantly reduces their differentiation into adipocytes (˜ 50 to 100nM). Exerts anti-adipogenic activity by down-regulating C/EBPa and PPARg. Shown to reduce adipocyte size and diminish weight gain in diet-induced obese mice without affecting their daily food intake.
TRUSTED_SUSTAINABILITY

Specifications

Color Yellow
Description 96% by HPLC
Target Proteins GSK3b
Molecular Formula C19H16ClNO6S
Solubility DMSO
Content And Storage Protect from light
Form Solid
Quantity 10 mg
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