MilliporeSigma™ Calbiochem™ HDAC6 Inhibitor II, BRD9757

Catalog No. 50-576-00001

Supplier: MilliporeSigma™ 5057600001

Description

A cell-permeable, low molecular weight hydroxamate compound that acts as a potent histone deacetylase class IIb HDAC6-selective inhibitor (IC₅₀ = 30nM), while inhibiting class I HDAC1/2/3/8 only at higher concentrations (IC₅₀

A cell-permeable, low molecular weight hydroxamate compound that acts as a potent histone deacetylase class IIb HDAC6-selective inhibitor (IC₅₀ = 30nM), while inhibiting class I HDAC1/2/3/8 only at higher concentrations (IC₅₀ = 0.638, 1.79, 0.694, and 1.09μM, respectively) and exhibiting much reduced potency against class IIa HDAC4/5/7/9 (IC₅₀ >12.61μM). Shown to selectively upregulate HDAC6 substrate α-tubulin acetylation in HeLa cells (10 and 30μM; 24 h) without inducing histone H3 acetylation increase seen with another HDAC6-selective inhibitor Tubastatin A (Cat. No. 382187). Unlike other Zinc-binding group-containing HDAC inhibitors, BRD9757 does not contain an apparent selectivity-imparting capping structure linked to its hydroxamate.

Specifications

• Color: Pale Orange
• Description: 98% by HPLC
• Target Proteins: HDAC6
• Molecular Formula: C₆H₉NO₂
• Solubility: DMSO
• Content And Storage: Protect from light
• Form: Solid
• Quantity: 10 mg