Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Protein Purification
  5. Protease Inhibitors and Phosphatase Inhibitors
  6. 5057600001

MilliporeSigma™ Calbiochem™ HDAC6 Inhibitor II, BRD9757

Catalog No. 5057600001 Shop All MilliporeSigma Products
Change view
Click to view available options
Quantity:
10 mg
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
50-576-00001 10 mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. 50-576-00001 Supplier MilliporeSigma™ Supplier No. 5057600001
Only null left
Add to Cart
Add to Cart

Description

A cell-permeable, low molecular weight hydroxamate compound that acts as a potent histone deacetylase class IIb HDAC6-selective inhibitor (IC50 = 30nM), while inhibiting class I HDAC1/2/3/8 only at higher concentrations (IC50

A cell-permeable, low molecular weight hydroxamate compound that acts as a potent histone deacetylase class IIb HDAC6-selective inhibitor (IC50 = 30nM), while inhibiting class I HDAC1/2/3/8 only at higher concentrations (IC50 = 0.638, 1.79, 0.694, and 1.09μM, respectively) and exhibiting much reduced potency against class IIa HDAC4/5/7/9 (IC50 >12.61μM). Shown to selectively upregulate HDAC6 substrate α-tubulin acetylation in HeLa cells (10 and 30μM; 24 h) without inducing histone H3 acetylation increase seen with another HDAC6-selective inhibitor Tubastatin A (Cat. No. 382187). Unlike other Zinc-binding group-containing HDAC inhibitors, BRD9757 does not contain an apparent selectivity-imparting capping structure linked to its hydroxamate.
TRUSTED_SUSTAINABILITY

Specifications

Color Pale Orange
Description 98% by HPLC
Target Proteins HDAC6
Molecular Formula C6H9NO2
Solubility DMSO
Content And Storage Protect from light
Form Solid
Quantity 10 mg
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.