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MilliporeSigma™ Calbiochem™ HIF Inhibitor V

Catalog No. 5004980001 Shop All MilliporeSigma Products
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50-049-80001 10 mg
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Catalog No. 50-049-80001 Supplier MilliporeSigma™ Supplier No. 5004980001
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Description

A cell-permeable phenoxyacrylamido compound that inhibits hypoxia-induced cellular HIF-1α accumulation in a manner similar to LW6 (Cat

A cell-permeable phenoxyacrylamido compound that inhibits hypoxia-induced cellular HIF-1α accumulation in a manner similar to LW6 (Cat. No. 400083) by upregulating Hippel-Lindau tumor suppressor gene product pVHL, but with much higher potency (IC50 = 120nM vs 2.44μM, respectively, against hypoxia-induced HRE reporter activity in HCT116 cells). Shown to suppress HIF-1 target genes expression in HCT116 cultures and inhibit HUVEC tubule formation (effective conc. ≥2μM) under hypoxia conditions.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
TRUSTED_SUSTAINABILITY

Specifications

Color White
Description 99% by HPLC
Molecular Formula C32H38N2O5
Formula Weight 530.7g/mol
Solubility DMSO
Content And Storage Protect from light
Form Powder
Quantity 10 mg
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