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MilliporeSigma™ Calbiochem™ HIF Inhibitor VII

Catalog No. 5043790001 Shop All MilliporeSigma Products
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50-437-90001 10 mg
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Catalog No. 50-437-90001 Supplier MilliporeSigma™ Supplier No. 5043790001
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Description

A cell-permeable benzoxadiazolamine that prevents HIF-2α-HIF-β/ARNT heterodimeration by perturbing HIF-2α Per-ARNT-Sim/PAS-B domain surface β-sheet conformation via a 1:1 stoichiometric binding ( K D = 81nM), while exhibiting no affinity toward HIF-1αPAS-B

A cell-permeable benzoxadiazolamine that prevents HIF-2α-HIF-β/ARNT heterodimeration by perturbing HIF-2α Per-ARNT-Sim/PAS-B domain surface β-sheet conformation via a 1:1 stoichiometric binding ( K D = 81nM), while exhibiting no affinity toward HIF-1αPAS-B domain. Shown to be metabolically stable and non-cytotoxic in cultures and selectively inhibit hypoxia-induced HIF-2α DNA binding and HIF-2α-dependent EPO mRNA upregulation (1 to10μM for 6 to 12 h), but not HIF-1α DNA binding or HIF-1α-dependent PGK1 mRNA upregulation, in Hep3B cells. Unlike HIF Inhibitors I-VI, this compound does not affect the cellular protein or mRNA levels of HIF-1α & HIF-2α.
TRUSTED_SUSTAINABILITY

Specifications

Color Yellow
Description 99% by HPLC
Target Proteins HIF-2α
Molecular Formula C12H6ClFN4O3
Solubility DMSO
Content And Storage Protect from light
Form Powder
Quantity 10 mg
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