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MilliporeSigma™ Calbiochem™ HIF Prolyl Hydroxylase Inhibitor

Catalog No. 40008410MG Shop All MilliporeSigma Products
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Quantity:
10 mg

Description

A cell-permeable, hydroxyquinoline HIF Prolyl Hydroxylase (PHD) inhibitor that displays an IC50 = 2μM in a cell-based assay using a reporter produced by fusing HIF-1α oxygen degradable domain (ODD) to lucifer

A cell-permeable, hydroxyquinoline HIF Prolyl Hydroxylase (PHD) inhibitor that displays an IC50 = 2μM in a cell-based assay using a reporter produced by fusing HIF-1α oxygen degradable domain (ODD) to luciferase. This compound (5μM) is shown to significantly stabilize HIF-1α in vitro and upregulate known HIF target genes, Epo and VEGF, in SH-SY5Y human neuroblastoma cell lines. It also exerts a neuroprotective effect (IC50 = 0.25μM in an oxidative stress model using cortical neurons.
TRUSTED_SUSTAINABILITY

Specifications

Color Tan
Description 95% by HPLC
CAS 385786-48-1
Molecular Formula C21H16ClN3O
Formula Weight 377.82g/mol
Solubility DMSO
Form Solid
Quantity 10 mg
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