MilliporeSigma™ Calbiochem™ Histone Acetyltransferase Inhibitor VIII, NU9056

Description

A cell-permeable disulfane compound that is reported to be more potent against KAT5/Tip60 than PCAF, p300, and GCN5 in cell-free HAT activity assays (IC₅₀ ≤2, ≤36, ≤60, and >100μM, respectively) and effectively reduce H3K14, H4K8, H4K16, but not α-tubulin, acetylation level in LNCaP prostate cancer cells (max inhibition at 5-10

A cell-permeable disulfane compound that is reported to be more potent against KAT5/Tip60 than PCAF, p300, and GCN5 in cell-free HAT activity assays (IC₅₀ ≤2, ≤36, ≤60, and >100μM, respectively) and effectively reduce H3K14, H4K8, H4K16, but not α-tubulin, acetylation level in LNCaP prostate cancer cells (max inhibition at 5-10μM). Shown to induce cell cycle arrest and apoptosis (17 to 24μM) in LNCaP cultures and exhibit antiproliferation activity in both androgen-responsive and androgen-independent CaP cultures (GI₅₀ from 7.5 to 27μM).

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

Specifications

• Color: Yellowish Brown
• Description: 97% by HPLC
• Target Proteins: KAT5
• Molecular Formula: C₆H₄N₂S₄
• Solubility: DMSO
• Content And Storage: Protect from light
• Form: Oil
• Quantity: 10 mg