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MilliporeSigma™ Calbiochem™ Histone Lysine Demethylase Inhibitor VIII, GSK-J4

Catalog No. 42020510MG Shop All MilliporeSigma Products
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42-020-510MG 10 mg
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Description

Histone Lysine Demethylase Inhibitor VIII, GSK-J4, CAS 1373423-53-0, is converted to GSK-J1 intracellularly for effective JMJD3 and UTX inhibition (∽ 25 to 50μM in HeLa cultures).

A cell-permeable GSK-J1 (Cat. No. 420204) prodrug that is ineffective in cell-free assays, but is effectively converted to GSK-J1 intracellularly for effective JMJD3 and UTX inhibition (effective conc. 25 to 50μM in HeLa cultures). GSK-J4 treatment is shown to block LPS-induced TNF-α production in primary human macrophage cultures (IC50 = 9μM by ELISA).

This probe is supplied in conjunction with the Structural Genomics Consortium (SGC). For further characterization details, please visit the SGC website (http://www.thesgc.org/scientists/chemical_probes/GSKJ1).
TRUSTED_SUSTAINABILITY

Specifications

Color Tan
Description 98% by HPLC
Target Proteins H3K27me3 demethylases JMJD3 & UTX
Molecular Formula C24H27N5O2
Formula Weight 417.5g/mol
Solubility DMSO
Content And Storage Protect from light
Form Semi-solid
Quantity 10 mg
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