MilliporeSigma™ Calbiochem™ Histone Lysine Methyltransferase Inhibitor

Description

The Histone Lysine Methyltransferase Inhibitor, also referenced under CAS 935693-62-2, controls the biological activity of Histone Lysine Methyltransferase. This small molecule/inhibitor is primarily used for Cancer applications.

A cell-permeable diazepinyl-quinazolinamine, non-SAM (S-adenosylmethionine) analog-based HMTase (histone methyltransferase) inhibitor that selectively interferes with the G9a-catalyzed H3K9me2 (histone H3 Lys9 dimethylation) modification (IC₅₀ = 1.7μM) in a reversible manner. It inhibits the GLP-catalyzed H3K9me3 only at much higher concentrations (IC₅₀ = 38μM) and exhibits little activity against H3 methylations catalyzed by other HMTases (PRMT1, SET7/9, ESET, SUV39H1). Shown to effectively synergize with Oct 3/4 and Klf 4 in inducing reprogramming of primary murine fetal NPCs (Neural Progenitor Cells) into iPS (induced Pluripotent Stem) cells without additional viral transduction of Sox2 and c- Myc .

Specifications

• Color: Off-white
• Description: 97% by HPLC
• CAS: 935693-62-2
• Molecular Formula: C₂₈H₃₈N₆O₂
• Formula Weight: 490.6g/mol
• Solubility: DMSO or EtOH
• Content And Storage: Protect from light
• Form: Solid
• Quantity: 5 mg