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MilliporeSigma™ Calbiochem™ Histone Lysine Methyltransferase Inhibitor

Catalog No. 3821905MG Shop All MilliporeSigma Products
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38-219-05MG 5 mg
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Catalog No. 38-219-05MG Supplier MilliporeSigma™ Supplier No. 3821905MG
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Description

The Histone Lysine Methyltransferase Inhibitor, also referenced under CAS 935693-62-2, controls the biological activity of Histone Lysine Methyltransferase. This small molecule/inhibitor is primarily used for Cancer applications.

A cell-permeable diazepinyl-quinazolinamine, non-SAM (S-adenosylmethionine) analog-based HMTase (histone methyltransferase) inhibitor that selectively interferes with the G9a-catalyzed H3K9me2 (histone H3 Lys9 dimethylation) modification (IC50 = 1.7μM) in a reversible manner. It inhibits the GLP-catalyzed H3K9me3 only at much higher concentrations (IC50 = 38μM) and exhibits little activity against H3 methylations catalyzed by other HMTases (PRMT1, SET7/9, ESET, SUV39H1). Shown to effectively synergize with Oct 3/4 and Klf 4 in inducing reprogramming of primary murine fetal NPCs (Neural Progenitor Cells) into iPS (induced Pluripotent Stem) cells without additional viral transduction of Sox2 and c- Myc .
TRUSTED_SUSTAINABILITY

Specifications

Color Off-white
Description 97% by HPLC
CAS 935693-62-2
Molecular Formula C28H38N6O2
Formula Weight 490.6g/mol
Solubility DMSO or EtOH
Content And Storage Protect from light
Form Solid
Quantity 5 mg
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