MilliporeSigma™ Calbiochem™ O-GlcNAcase Inhibitor, TMG
A cell-permeable, blood-brain barrier-permeant, orally active aminothiazoline that effectively increases O -GlcNAc level of cellular proteins both in cultures (EC50 = 30 nM, ECmax = 200nM in PC3) in vitro and in rats
Manufacturer: MilliporeSigma™ 110165CBC25MG
DescriptionA cell-permeable, blood-brain barrier-permeant, orally active aminothiazoline that effectively increases O -GlcNAc level of cellular proteins both in cultures (EC50 = 30 nM, ECmax = 200nM in PC3) in vitro and in rats (50mg/kg i.v.; 200mg/kg via drinking water ad libitum ) and mice (500mg/kg via drinking water ad libitum ) in vivo by inhibiting O-GlcNAcase/OGA-mediated O -GlcNAc cleavage in a substrate-competitive ( K i = 21nM), time- and dose-dependent, and highly selective manner. TMG long-term treatment in murine AD model effectively prevents loss of motor neurons and reduces NFTs in brain without apparent effect on Tau hyperphosphorylation. O -GlcNAcylation is also reported to slow down heat-induced sTAB1 (TAK1-binding protein) aggregation and modulate CK2α kinase activity and substrate selectivity in vitro .
|DMSO or H2O|
|≥98% by HPLC|
Store at −20°C
Protect from light
Following reconstitution, aliquot and freeze (−20°C). Stock solutions are stable for up to 6 months at −20°C.
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