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MilliporeSigma™ Calbiochem™ O-GlcNAcase Inhibitor, TMG
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Quantity:
25 mg
Description
A cell-permeable, blood-brain barrier-permeant, orally active aminothiazoline that effectively increases O -GlcNAc level of cellular proteins both in cultures (EC50 = 30 nM, ECmax = 200nM in PC3) in vitro and in rats (50mg/kg i.v.; 200mg/kg via drinking water ad libitum ) and mice (500mg/kg via drinking water ad libitum ) in vivo by inhibiting O-GlcNAcase/OGA-mediated O -GlcNAc cleavage in a substrate-competitive ( K i = 21nM), time- and dose-dependent, and highly selective manner. TMG long-term treatment in murine AD model effectively prevents loss of motor neurons and reduces NFTs in brain without apparent effect on Tau hyperphosphorylation. O -GlcNAcylation is also reported to slow down heat-induced sTAB1 (TAK1-binding protein) aggregation and modulate CK2α kinase activity and substrate selectivity in vitro .

Specifications
Specifications
Color | Off-white |
Description | ≥98% by HPLC |
CAS | 1009816-48-1 |
Molecular Formula | C9H16N2O4S |
Formula Weight | 248.3g/mol |
Solubility | DMSO or H2O |
Content And Storage | Toxicity: Harmful, Store at -20°C, Protect from light, Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. |
Form | Solid |
Quantity | 25 mg |
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