Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
MilliporeSigma™ Calbiochem™ O-GlcNAcase Inhibitor, TMG
A cell-permeable, blood-brain barrier-permeant, orally active aminothiazoline that effectively increases O -GlcNAc level of cellular proteins both in cultures (EC50 = 30 nM, ECmax = 200nM in PC3) in vitro and in rats
Manufacturer: MilliporeSigma™ 110165CBC25MG
Description
A cell-permeable, blood-brain barrier-permeant, orally active aminothiazoline that effectively increases O -GlcNAc level of cellular proteins both in cultures (EC50 = 30 nM, ECmax = 200nM in PC3) in vitro and in rats (50mg/kg i.v.; 200mg/kg via drinking water ad libitum ) and mice (500mg/kg via drinking water ad libitum ) in vivo by inhibiting O-GlcNAcase/OGA-mediated O -GlcNAc cleavage in a substrate-competitive ( K i = 21nM), time- and dose-dependent, and highly selective manner. TMG long-term treatment in murine AD model effectively prevents loss of motor neurons and reduces NFTs in brain without apparent effect on Tau hyperphosphorylation. O -GlcNAcylation is also reported to slow down heat-induced sTAB1 (TAK1-binding protein) aggregation and modulate CK2α kinase activity and substrate selectivity in vitro .Specifications
1009816-48-1 | |
Off-white solid | |
C9H16N2O4S | |
DMSO or H2O |
≥98% by HPLC | |
248.3g/mol | |
25mg | |
Toxicity: Harmful Store at −20°C Protect from light Following reconstitution, aliquot and freeze (−20°C). Stock solutions are stable for up to 6 months at −20°C. |
Provide Content Correction
We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.
Product Title