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MilliporeSigma™ Calbiochem™ IM-412

Catalog No. 40125110MG Shop All MilliporeSigma Products
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Quantity:
10 mg

Description

IM-412 primarily used in Inhibition.

A cell permeable imidazoxanthine shown to decrease TGF-β stimulated reporter activity in a dose-dependent manner in HEK293 reporter cells, with an IC50 of 4.1μM without cell cytotoxicity. Inhibits TGF-β receptor I (TβRI) and TGF-β receptor II (TβRII) expression and its downstream Smad2 and Smad3 phosphorylation as well as JNK and ERK activity. In addition, it elicits TGF-β-induced fibroblast differentiation with attenuated expression of several fibrotic markers such as α-SMA and fibronectin, and suppresses collagen accumulation in CCD-18Lu human normal lung fibroblasts.
TRUSTED_SUSTAINABILITY

Specifications

Color Off-white
Description 90% by HPLC
Molecular Formula C16H14ClN5O2
Formula Weight 343.77g/mol
Solubility DMSO or EtOH
Form Solid
Quantity 10 mg
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