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  6. 6585481MG

MilliporeSigma™ Calbiochem™ InSolution™ AG 1478

Catalog No. 6585481MG Shop All MilliporeSigma Products
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Quantity:
1 mg

Description

Highly potent and specific inhibitor of the epidermal growth factor (EGF) receptor tyrosine kinase (IC50 = 3nM)

Highly potent and specific inhibitor of the epidermal growth factor (EGF) receptor tyrosine kinase (IC50 = 3nM). Much higher concentrations are required for inhibition of the kinase activity of the closely related HER2 ( neu/erb -B2) receptor (IC50 > 100μM), the platelet-derived growth factor (PDGF) receptor (IC50 > 100μM), and p210Bcr-Abl (IC50 >50μM). Its mechanism of inhibition likely mimics that of the related compound, 4-(3-chloroanilino)quinazoline (CAQ), a competitive inhibitor with respect to ATP.
TRUSTED_SUSTAINABILITY

Specifications

Color Clear to Faint Tan
Formulation A 10 mM (1mg/317μl) solution of AG 1478 in DMSO.
Description 98% by HPLC
Target Proteins Epidermal growth factor receptor kinase
CAS 175178-82-2
Molecular Formula C16H14ClN3O2
Formula Weight 315.8g/mol
Content And Storage Protect from light
Form Liquid
Quantity 1 mg
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