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  6. 6584115MG

MilliporeSigma™ Calbiochem™ InSolution™ AG490

Catalog No. 6584115MG Shop All MilliporeSigma Products
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Quantity:
5 mg

Description

Potent inhibitor of epidermal growth factor receptor kinase autophosphorylation (IC50 = 100nM)

Potent inhibitor of epidermal growth factor receptor kinase autophosphorylation (IC50 = 100nM). Jak family tyrosine kinase inhibitor. Inhibition of Jak2 by AG 490 selectively blocks leukemic cell growth in vitro and in vivo by inducing programmed cell death, with no harmful effect on normal haematopoiesis. Inhibits the constitutive activation of STAT-3 and IL-2-induced growth of MF tumor cells. AG 490 has also been shown to inhibit the autokinase activity of JAK3. Also reported to inhibit guanylyl cyclase.
TRUSTED_SUSTAINABILITY

Specifications

Formulation A 100 mM (5mg/170μl) solution of AG490 in DMSO.
Description 98% by HPLC
Molecular Formula C17H14N2O3
Formula Weight 294.3g/mol
Content And Storage Hygroscopic, Protect from light
Form Liquid
Quantity 5 mg
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