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MilliporeSigma™ Calbiochem™ InSolution™ Batimastat

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50-840-80001 2 mg
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Description

A Marimastat type of peptidyl hydroxamate-based inhibitor that potently inhibits a broad-spectrum of metalloproteinases

A Marimastat (Cat. No. 444289) type of peptidyl hydroxamate-based inhibitor that potently inhibits a broad-spectrum of metalloproteinases, including MMP-1, MMP-2, MMP-3/stromelysin, MMP-7/matrilysin, MMP-9, δMT1 (MMP-14 without TM domain), ADAM8, and ADAM17/TACE (IC50 = 3, 4, 20, 6, 4, 2.08, 51.3, and 19 nM, respectively), by targeting both the substrate binding site and the active-site Zn2+, while being much less potent toward ACE (Angiotensin Converting Enzyme) or α-secretase (IC50 = 1.6 and 3.3μM, respectively). Batimastat is widely used in studying the involvement of MMPs in cancinogenesis and non-cancer pathological processes both in cultures in vitro and in animals in vivo .
TRUSTED_SUSTAINABILITY

Specifications

Formulation A 25 mM (2mg/168μL) sterile-filtered solution of Batimastat in DMSO.
Description 97% by HPLC
Target Proteins MMPs
Molecular Formula C23H31N3O4S2
Formula Weight 477.6g/mol
Content And Storage Avoid Freeze-Thaw Cycles, Hygroscopic, Protect from Light
Form Liquid
Quantity 2 mg
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