MilliporeSigma™ Calbiochem™ InSolution™ CFTR Inhibitor II, GlyH-101

Description

A cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (<1 min; 95% inhibition at 50μM; K_i

A cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (<1 min; 95% inhibition at 50μM; K_i = 4.3μM in CFTR-expressing FRT cells for apical membrane Cl^- current) and exhibits desirable aqueous solubility. Shown to produce inwardly rectifying CFTR Cl^- currents with reduced mean channel open time and suggested to directly interact with the channel pore at the extracellular side of the membrane. Displays minimal effects on P-glycoprotein and non-CFTR-mediated Cl^- currents, and is effective in nasal and intestinal epithelia in vivo .

Specifications

• Formulation: A 25 mM (5mg/406μL) solution of CFTR Inhibitor II, GlyH-101 in DMSO.
• Description: 97% by HPLC
• Target Proteins: CFTR
• Molecular Formula: C₁₉H₁₅Br₂N₃O₃
• Formula Weight: 493.2g/mol
• Content And Storage: Avoid Freeze-Thaw Cycles, Hygroscopic, Protect from Light
• Form: Liquid
• Quantity: 5 mg