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MilliporeSigma™ Calbiochem™ InSolution™ CFTR Inhibitor II, GlyH-101

Catalog No. 2196755MG Shop All MilliporeSigma Products
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21-967-55MG 5 mg
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Description

A cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (<1 min; 95% inhibition at 50μM; Ki

A cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (<1 min; 95% inhibition at 50μM; Ki = 4.3μM in CFTR-expressing FRT cells for apical membrane Cl- current) and exhibits desirable aqueous solubility. Shown to produce inwardly rectifying CFTR Cl- currents with reduced mean channel open time and suggested to directly interact with the channel pore at the extracellular side of the membrane. Displays minimal effects on P-glycoprotein and non-CFTR-mediated Cl- currents, and is effective in nasal and intestinal epithelia in vivo .
TRUSTED_SUSTAINABILITY

Specifications

Formulation A 25 mM (5mg/406μL) solution of CFTR Inhibitor II, GlyH-101 in DMSO.
Description 97% by HPLC
Target Proteins CFTR
Molecular Formula C19H15Br2N3O3
Formula Weight 493.2g/mol
Content And Storage Avoid Freeze-Thaw Cycles, Hygroscopic, Protect from Light
Form Liquid
Quantity 5 mg
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