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MilliporeSigma™ Calbiochem™ InSolution™ eIF4E/eIF4G Interaction Inhibitor, 4EGI-1

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32-451-95MG 5 mg
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Description

A cell-permeable hydrazone compound that reversibly binds eukaryotic translation initiation factor 4E (eIF4E; KD = 25μM) and disrupts eIF4E/eIF4G, but not eIF4E/4E-BP1, complex format

A cell-permeable hydrazone compound that reversibly binds eukaryotic translation initiation factor 4E (eIF4E; KD = 25μM) and disrupts eIF4E/eIF4G, but not eIF4E/4E-BP1, complex formation. Reported to downregulate the protein, but not mRNA, levels of c-Myc and Bcl-xL in Jurkat cells (8 hrs), leading to apoptotic cell death after prolonged exposure (24 hrs, IC50 ∽25μM). Shown to be brain permeant and reduce neuroligin protein levels, and restore L-LTP threshold and rescue autistic-like behaviours in Eif4ebp2 knockout mice.
TRUSTED_SUSTAINABILITY

Specifications

Formulation A 25 mM (5mg/443μL) solution of eIF4E/eIF4G Interaction Inhibitor, 4EGI-1
Description 95% by HPLC (sum of two isomers)
Target Proteins eIF4E
CAS 315706-13-9
Molecular Formula C18H12Cl2N4O4S
Formula Weight 451.3g/mol
Content And Storage Avoid Freeze-Thaw Cycles, Hygroscopic, Protect from Light
Form Liquid
Quantity 5 mg
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