MilliporeSigma™ Calbiochem™ InSolution™ Glutaminase Inhibitor, Compound 968

Description

A cell-permeable benzophenanthridinone compound that acts as an allosteric and reversible inhibitor of mitochondrial glutaminase activity and represses the growth and invasive activity in glutaminase upregulated fibroblasts and in tumor cells (IC₅₀ ≤ 10μM in NIH3T3 cells stably expressing Dbl, Cdc42-F28L, Rac-F28L or RhoC-F30L mutants and in SKBR3 and MDA-MB231 cancer cel

A cell-permeable benzophenanthridinone compound that acts as an allosteric and reversible inhibitor of mitochondrial glutaminase activity and represses the growth and invasive activity in glutaminase upregulated fibroblasts and in tumor cells (IC₅₀ ≤ 10μM in NIH3T3 cells stably expressing Dbl, Cdc42-F28L, Rac-F28L or RhoC-F30L mutants and in SKBR3 and MDA-MB231 cancer cells). Shown to effectively shrink tumor size in P-493 B xenografted mouse model (200μg per inj. i.p., 12 days).

Specifications

• Formulation: A 10 mM (5mg/1.05mL) sterile-filtered solution of Glutaminase Inhibitor, Compound 968 in DMSO.
• Description: 99% by HPLC
• Target Proteins: mitochondrial glutaminase
• Molecular Formula: C₂₇H₂₇BrN₂O
• Formula Weight: 475.4g/mol
• Content And Storage: Avoid Freeze-Thaw Cycles, Hygroscopic, Protect from Light
• Form: Liquid
• Quantity: 5 mg