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  6. 420297100UG

MilliporeSigma™ Calbiochem™ InSolution™ K-252a, Nocardiopsis sp.

Catalog No. 420297100UG
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Quantity:
100 μg

Description

A cell-permeable protein kinase inhibitor that inhibits CaM kinase II (Ki = 1

A cell-permeable protein kinase inhibitor that inhibits CaM kinase II (Ki = 1.8nM), myosin light chain kinase (Ki = 17nM), protein kinase A (Ki = 18nM), protein kinase C (Ki = 25nM), and protein kinase G (Ki = 20nM). Also acts as a potent inhibitor (IC50 = 3nM) of the tyrosine protein kinase activity of the NGF receptor gp 140trk, the product of the trk protooncogene. Also inhibits the kinase activity of its transforming alleles, the trk oncogenes, and of the related neurotrophin receptors gp 145trkB and gp 145trkC. Induces apoptosis and cell cycle arrest by inhibiting Cdc2 and Cdc25c.
TRUSTED_SUSTAINABILITY

Specifications

Formulation A 1 mM (100μg/214μl) solution of K-252a in DMSO.
Description 95% by HPLC
Target Proteins CaM kinase II
CAS 97161-97-2
Molecular Formula C27H21N3O5
Formula Weight 467.5g/mol
Content And Storage Hygroscopic, Protect from light
Form Liquid
Quantity 100 μg
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