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MilliporeSigma™ Calbiochem™ InSolution™ Microcystin-LR, Microcystis aeruginosa

Cyclic heptapeptide toxin isolated from the freshwater cyanobacteria, Microcystis aeruginosa

Manufacturer:  MilliporeSigma™ 475821250UG

Catalog No. 47-582-1250UG


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Description

Description

Cyclic heptapeptide toxin isolated from the freshwater cyanobacteria, Microcystis aeruginosa . Potent inhibitor of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A). Unlike Okadaic Acid (Cat. No. 495604), microcystin-LR is effective on both PP1 (IC50 = 1.7nM) and PP2A (IC50 = 40 pM). Reacts with phosphatase in a two-step mechanism involving rapid binding and inactivation of the catalytic subunit followed by slower covalent interactions. Has no effect on protein kinases, making it useful for reducing contaminating phosphatase activities in protein kinase assays.
Specifications

Specifications

A 2.5 mM (250μg/100μl) solution of Microcystin-LR, Microcystis aeruginosa in DMSO.
Liquid
250μg
C49H74N10O12
95% by HPLC
Hygroscopic
Protect from Light
protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A)
995.2g/mol
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