MilliporeSigma Calbiochem InSolution Microcystin-LR, Microcystis aeruginosa
Cyclic heptapeptide toxin isolated from the freshwater cyanobacteria, Microcystis aeruginosa
Manufacturer: MilliporeSigma 475821250UG
DescriptionCyclic heptapeptide toxin isolated from the freshwater cyanobacteria, Microcystis aeruginosa . Potent inhibitor of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A). Unlike Okadaic Acid (Cat. No. 495604), microcystin-LR is effective on both PP1 (IC50 = 1.7nM) and PP2A (IC50 = 40 pM). Reacts with phosphatase in a two-step mechanism involving rapid binding and inactivation of the catalytic subunit followed by slower covalent interactions. Has no effect on protein kinases, making it useful for reducing contaminating phosphatase activities in protein kinase assays.
|A 2.5 mM (250μg/100μl) solution of Microcystin-LR, Microcystis aeruginosa in DMSO.|
|95% by HPLC|
Protect from Light
|protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A)|
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