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MilliporeSigma™ Calbiochem™ InSolution™ Necrostatin-1

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50-522-40001 10 mg
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Catalog No. 50-522-40001 Supplier MilliporeSigma™ Supplier No. 5052240001
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Description

A cell-permeable, potent, and selective blocker of necroptosis (EC50 = 494nM in FADD-deficient Jurkat cells treated with TNF-α), a nonapoptotic necrotic cell death pathway mediated by death-domain receptors (DRs) that offers neuroprotection in a murine model of ischemic brain inj

A cell-permeable, potent, and selective blocker of necroptosis (EC50 = 494nM in FADD-deficient Jurkat cells treated with TNF-α), a nonapoptotic necrotic cell death pathway mediated by death-domain receptors (DRs) that offers neuroprotection in a murine model of ischemic brain injury. Exhibits no effect on DR-induced apoptosis. Also acts as a selective and ATP-competitive inhibitor of RIP1 kinase with negligible effect on RIP2 kinase activity. Nec-1 target appears to be a critical common necroptotic step upstream of execution events and downstream of DRs. Inactive control, Nec-1i, is also available ( Cat. No. 480066).
TRUSTED_SUSTAINABILITY

Specifications

Formulation A 25 mM (10mg/1.54mL) sterile-filtered solution of Necrostatin-1 in DMSO.
Description 99% by HPLC
Molecular Formula C13H13N3OS
Formula Weight 259.3g/mol
Content And Storage Avoid Freeze-Thaw Cycles, Hygroscopic, Protect from Light
Form Liquid
Quantity 10 mg
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