MilliporeSigma™ Calbiochem™ InSolution™ Necrostatin-1

Description

A cell-permeable, potent, and selective blocker of necroptosis (EC₅₀ = 494nM in FADD-deficient Jurkat cells treated with TNF-α), a nonapoptotic necrotic cell death pathway mediated by death-domain receptors (DRs) that offers neuroprotection in a murine model of ischemic brain inj

A cell-permeable, potent, and selective blocker of necroptosis (EC₅₀ = 494nM in FADD-deficient Jurkat cells treated with TNF-α), a nonapoptotic necrotic cell death pathway mediated by death-domain receptors (DRs) that offers neuroprotection in a murine model of ischemic brain injury. Exhibits no effect on DR-induced apoptosis. Also acts as a selective and ATP-competitive inhibitor of RIP1 kinase with negligible effect on RIP2 kinase activity. Nec-1 target appears to be a critical common necroptotic step upstream of execution events and downstream of DRs. Inactive control, Nec-1i, is also available ( Cat. No. 480066).

Specifications

• Formulation: A 25 mM (10mg/1.54mL) sterile-filtered solution of Necrostatin-1 in DMSO.
• Description: 99% by HPLC
• Molecular Formula: C₁₃H₁₃N₃OS
• Formula Weight: 259.3g/mol
• Content And Storage: Avoid Freeze-Thaw Cycles, Hygroscopic, Protect from Light
• Form: Liquid
• Quantity: 10 mg