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MilliporeSigma™ Calbiochem™ InSolution™ Nutlin-3, Racemic

Catalog No. 4441511MG Shop All MilliporeSigma Products
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Description

A cell-permeable, potent, and selective MDM2 antagonist (IC50 = 90nM for Nutlin-3a and 13

A cell-permeable, potent, and selective MDM2 antagonist (IC50 = 90nM for Nutlin-3a and 13.6μM for Nutlin-3b) that displays antitumor properties. Activates the p53 pathway by binding MDM2 in the p53-binding pocket and inhibiting the MDM2-p53 interaction. Shown to induce apoptosis in several cancer cell lines with wild-type p53 and in xenografted tumor mice.
TRUSTED_SUSTAINABILITY

Specifications

Formulation A 10 mM (1mg/172μl) solution of MDM2 Antagonist, Nutlin-3, Racemic in DMSO
Description 98% by HPLC
Molecular Formula C30H30Cl2N4O4
Formula Weight 581.5g/mol
Content And Storage Hygroscopic, Protect from light
Form Liquid
Quantity 1 mg
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