MilliporeSigma Calbiochem InSolution OM99-2
An eight residue peptidomimetic, tight binding transition-state analog inhibitor of human brain memapsin 2.
Manufacturer: MilliporeSigma 496000250UG
DescriptionAn eight residue peptidomimetic, tight binding transition-state analog inhibitor of human brain memapsin 2 (Ki = 1.6 nM, recombinant memapsin 2; Ki = 9.58 nM, recombinant pro-memapsin 2). Also inhibits cathepsin D (Ki = 48nM). This aspartyl protease inhibitor is designed from the template of the β-secretase site of Swedish β-amyloid precursor protein (APP) with Asp to Ala replacement; also includes a nonhydrolyzable hydroxyethylene isostere between Leu and Ala.
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|A 1 mM (250μg in 280μl) solution in DMSO. Supplied as a trifluoroacetate salt.|
|90% by HPLC|
|Protect from Light
Protect from Moisture
|human brain memapsin 2|
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