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MilliporeSigma™ Calbiochem™ InSolution™ Phorbol-12-myristate-13-acetate

Most commonly-used phorbol ester

Supplier:  MilliporeSigma™ 5.00582.0001

Catalog No. 50-058-20001


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Description

Description

Most commonly-used phorbol ester. Extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro , even atnM concentrations. Promotes the expression of iNOS in cultured hepatocytes. Activates Ca2+-ATPase and potentiates forskolin (Cat. No. 344270, Cat. No. 344282)-induced cAMP formation. Inhibits apoptosis induced by the Fas antigen, but induces apoptosis in HL-60 promyelocytic leukemia cells. Its binding is reversible.
Specifications

Specifications

A 10 mM (2mg/324μL) solution of Phorbol-12-myristate-13-acetate in DMSO.
PKC
616.8g/mol
Liquid
98% by HPLC
C36H56O8
Avoid Freeze-Thaw Cycles, Hygroscopic, Protect from Light
2 mg
SDS
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