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MilliporeSigma™ Calbiochem™ InSolution™ Phorbol-12-myristate-13-acetate
GSA_VA

Catalog No. 5005820001 Shop All MilliporeSigma Products
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50-058-20001 2 mg
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Catalog No. 50-058-20001 Supplier MilliporeSigma™ Supplier No. 5005820001
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Description

Most commonly-used phorbol ester

Most commonly-used phorbol ester. Extremely potent mouse skin tumor promoter. Activates protein kinase C in vivo and in vitro , even atnM concentrations. Promotes the expression of iNOS in cultured hepatocytes. Activates Ca2+-ATPase and potentiates forskolin (Cat. No. 344270, Cat. No. 344282)-induced cAMP formation. Inhibits apoptosis induced by the Fas antigen, but induces apoptosis in HL-60 promyelocytic leukemia cells. Its binding is reversible.

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TRUSTED_SUSTAINABILITY

Specifications

Formulation A 10 mM (2mg/324μL) solution of Phorbol-12-myristate-13-acetate in DMSO.
Description 98% by HPLC
Target Proteins PKC
Molecular Formula C36H56O8
Formula Weight 616.8g/mol
Content And Storage Avoid Freeze-Thaw Cycles, Hygroscopic, Protect from Light
Form Liquid
Quantity 2 mg
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