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MilliporeSigma™ Calbiochem™ InSolution™ Roscovitine

Catalog No. 5573645MG Shop All MilliporeSigma Products
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55-736-45MG 5 mg
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Description

A potent and selective inhibitor of cyclin-dependent kinases (Cdks)

A potent and selective inhibitor of cyclin-dependent kinases (Cdks). Exhibits greater inhibitory potency compared to olomoucine (Cat. No. 495620). Inhibits p34 Cdc2/cyclin B (IC50 = 650nM), p33 Cdk2/cyclin A (IC50 = 700nM), p33 Cdk2/cyclin E (IC50 = 700nM), and p33 Cdk2/p35 (IC50 = 200nM) by competing for the ATP binding domain of these kinases. Exhibits very low sensitivity towards related kinases, such as Erk1 and Erk2 (IC50 = 34μM and 14μM, respectively). Roscovitine does not significantly affect the activity of other protein kinases even at 100μM and compared to olomoucine, roscovitine displays increased anti-mitotic activity at the G1/S and G2/M phases of the cell cycle.
TRUSTED_SUSTAINABILITY

Specifications

Formulation A 50 mM (5mg/282μl) solution of Roscovitine in DMSO.
Description 95% by HPLC
Target Proteins p34cdk1/cyclin B
Molecular Formula C19H26N6O
Formula Weight 354.5g/mol
Content And Storage Hygroscopic, Protect from light
Form Liquid
Quantity 5 mg
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