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MilliporeSigma™ Calbiochem™ InSolution™ SB 202190

Catalog No. 5593971ML Shop All MilliporeSigma Products
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Description

A potent and cell-permeable inhibitor of p38 MAP kinase

A potent and cell-permeable inhibitor of p38 MAP kinase. Inhibits p38 phosphorylation of myelin basic protein (MBP) with no effect on the activity of the ERK or JNK MAP kinase subgroups. Also inhibits the kinase activity of p38β (IC50 = 350nM) and p38 phosphorylation of activating transcription factor 2 (ATF-2; IC50 = 280nM). Blocks LPS-induced TNF-α and interleukin biosynthesis. Reported to block LDL expression in Hep52 cells.
TRUSTED_SUSTAINABILITY

Specifications

Formulation A 1mg/mL solution of SB 202190 in anhydrous DMSO.
Description 98% by HPLC
Target Proteins P38β
CAS 152121-30-7
Molecular Formula C20H14FN3O
Formula Weight 331.1g/mol
Content And Storage Protect from light
Form Liquid
Quantity 1 mL
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