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MilliporeSigma™ Calbiochem™ InSolution™ Sirtinol

Catalog No. 5663211MG Shop All MilliporeSigma Products
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Description

A cell-permeable 2-hydroxy-1-napthaldehyde derivative that acts as a specific and a direct inhibitor of sirtuin class of histone deacetylase (HDAC) activity

A cell-permeable 2-hydroxy-1-napthaldehyde derivative that acts as a specific and a direct inhibitor of sirtuin class of histone deacetylase (HDAC) activity. Does not affect human HDAC1. Reported to block Sir2p transcriptional silencing activity in vivo (IC50 = 25μM) and NAD-dependent HDAC activity in purified recombinant yeast Sir2p and human SIRT2 in vitro (IC50 = 68μM and 38μM, respectively).
TRUSTED_SUSTAINABILITY

Specifications

Formulation A 10 mM (1mg/254μl) solution of Sirtinol in DMSO.
Description 97% by HPLC
Target Proteins ySir2
Molecular Formula C26H22N2O2
Formula Weight 394.5g/mol
Content And Storage Hygroscopic, Protect from light
Form Liquid
Quantity 1 mg
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