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MilliporeSigma™ Calbiochem™ InSolution™ TGF-β RI Kinase Inhibitor II, RepSox

Catalog No. 5081580001
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5mg

Description

A cell-permeable, potent, selective, reversible, and ATP-competitive inhibitor of TGF-β type I receptor (ALK5; IC50 = 23 nM, 4nM and 18nM for ALK5 binding, ALK5 auto-phosphorylation, and TGF-β cellular assay in HepG2 cells, respectively)

A cell-permeable, potent, selective, reversible, and ATP-competitive inhibitor of TGF-β type I receptor (ALK5; IC50 = 23 nM, 4nM and 18nM for ALK5 binding, ALK5 auto-phosphorylation, and TGF-β cellular assay in HepG2 cells, respectively). Minimally affects a panel of 9 closely related kinases including p38 MAPK (IC50 >16μM).
TRUSTED_SUSTAINABILITY

Specifications

Formulation A 50 mM (5mg/348μl) sterile-filtered solution of TGF-β RI Kinase Inhibitor II, RepSox in DMSO.
Description 99% by HPLC
Target Proteins ALK5
Molecular Formula C17H13N5
Formula Weight 287.3g/mol
Content And Storage Avoid Freeze-Thaw Cycles, Hygroscopic, Protect from Light
Form Liquid
Quantity 5 mg
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