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MilliporeSigma™ Calbiochem™ IRAK4 Inhibitor, Compound 26

Catalog No. 5312370001 Shop All MilliporeSigma Products
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53-123-70001 10 mg
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Catalog No. 53-123-70001 Supplier MilliporeSigma™ Supplier No. 5312370001
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Description

A cell permeable indolo[2,3-c]quinoline derivatived compound that acts as a selective and highly potent inhibitor of interleukin-1 receptor associated kinase (IRAK4; IC50 = 94

A cell permeable indolo[2,3-c]quinoline derivatived compound that acts as a selective and highly potent inhibitor of interleukin-1 receptor associated kinase (IRAK4; IC50 = 94 pM). Displays much reduced potency against IRAK1 (IC50 = 65nM) and displays high selectivity over a panel of other 27 kinases, including several involved in TLR-mediated signaling. Blocks R848-induced TNF-α and IL-6 production in primary human monocytes and inhibits LPS-induced TNF-α production in mice (100 mpk). Shows minimal inhibition of Cyp2C9, 2D6, and 3A4 and has excellent microsomal stability and desirable aqueous solubility (100mg/mL at pH 7.4).

Please note that the molecular weight for this compound is batch-specific due to variable water content.
TRUSTED_SUSTAINABILITY

Specifications

Color Pale Yellow
Description 98% by HPLC
Target Proteins IRAK4
Molecular Formula C25H27N5O2
Solubility DMSO
Content And Storage Protect from light
Form Powder
Quantity 10 mg
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