Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Protein Purification
  5. Protease Inhibitors and Phosphatase Inhibitors
  6. 42015110MG

MilliporeSigma™ Calbiochem™ JAK2 Inhibitor IX, WP1193

Catalog No. 42015110MG Shop All MilliporeSigma Products
Change view
Click to view available options
Quantity:
10 mg
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
42-015-110MG 10 mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. 42-015-110MG Supplier MilliporeSigma™ Supplier No. 42015110MG

Description

A cell-permeable tyrphostin WP1130 (Cat

A cell-permeable tyrphostin WP1130 (Cat. No. 681685) analog that inhibits JAK2 kinase activity (by >90% at 2.5μM in in vitro kinase assays) and effectively suppresses JAK2-dependent STAT3 Tyr705 phosphorylation in murine melanoma B16 and human GSC (glioma stem-like cell) cultures (5μM), as well as JAK2-dependent Bcr-Abl Tyr177 phosphorylation in primary human CML PBMCs, Imatinib/STI571-sensitive 32DP210, and IM-resistant Ba/F3-T315I murine leukemia lines (10μM). Reported to inhibit the growths of IM-resistant K562-R and T315I+ 32D in murine leukemia models (30mg/kg via i.p.; q.o.d.), as well as synergize with INF-α in suppressing B16 blood-to-lung metastasis and eliminating LMD (lentiginous melanocytic dysplasia) in mice died from established B26-derived brain tumor (30 mg WP1130/kg via o.g./oral gavage) in vivo .
TRUSTED_SUSTAINABILITY

Specifications

Color Brown
Description 95% by HPLC
Target Proteins JAK2
Formula Weight 382.3g/mol
Solubility MeOH
Content And Storage Protect from light
Form Solid
Quantity 10 mg
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.