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MilliporeSigma™ Calbiochem™ L- Buthionine Sulfoximine

Catalog No. 5082280001 Shop All MilliporeSigma Products
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50-822-80001 100 mg
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Catalog No. 50-822-80001 Supplier MilliporeSigma™ Supplier No. 5082280001
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Description

A cell-permeable, sulfoximine based compound that acts a potent, fast acting, irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels

A cell-permeable, sulfoximine based compound that acts a potent, fast acting, irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. Closely resembles the structure of g-glutamylphosphate cysteine adduct. The inhibition follows the first order kinetics with t1/2 = ∽ 11 sec at saturating inhibitor concentration. Does not affect the activity of glutamine synthetase. Shown to improve the outcome of chemotherapy by lowering the levels of glutathione in cancer cells (IC50 = 1.9, 8.6, and 29μM in melanoma, breast, and ovarian tumor cells, respectively).
TRUSTED_SUSTAINABILITY

Specifications

Color White
Description 97% by TLC
Target Proteins gamma-glutamylcysteine synthetase
Molecular Formula C8H18N2O3S
Solubility H2O
Content And Storage Protect from light
Form Powder
Quantity 100 mg
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