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MilliporeSigma™ Calbiochem™ Lactate Dehydrogenase A Inhibitor, FX11

Catalog No. 42721810MG Shop All MilliporeSigma Products
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42-721-810MG 10 mg
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Description

Lactate Dehydrogenase A Inhibitor, FX11, CAS 213971-34-7, is a cell permeable, selective, reversible, NADH competitive inhibitor of lactate dehhydrogenase A (LDHA; Ki = 8μM for human liver LDHA).

A cell permeable, gossypol analog that acts as a selective, reversible, and NADH competitive inhibitor of lactate dehhydrogenase A (LDHA; Ki = 8μM for human liver LDHA). Does not affect the activities of LDHB and glyceraldehyde-3-phosphate dehydrogenase even at higher concentrations. Shown to increase oxygen consumption, reactive oxygen species production, and cell death in P493 human lymphoma B cells. Also shown to reduce mitochondrial transmembrane potential and ATP levels and increase AMP kinase activity. Exhibits synergistic toxicity in P493 cells when combined with FK866 (Cat. No. 481908). Blocks the progression of human lymphoma and pancreatic cancer xenografts and when used in combination with FK866 it induces lymphoma regression.
TRUSTED_SUSTAINABILITY

Specifications

Color White
Description 96% by HPLC
Target Proteins LDHA
Molecular Formula C22H22O4
Solubility DMSO
Content And Storage Protect from light
Form Solid
Quantity 10 mg
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