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MilliporeSigma™ Calbiochem™ Leukadherin-1

Catalog No. 43461025MG Shop All MilliporeSigma Products
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Catalog No. Quantity
43-461-025MG 25 mg
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Catalog No. 43-461-025MG Supplier MilliporeSigma™ Supplier No. 43461025MG
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Description

A furanyl thiazolidinone compound that binds CD11b αA/αI domain in a reversible manner and stabilizes αA in a high-affinity binding conformation toward known CD11b/CD18 (αMβ2; CR3; Mac-1) ligands, fibrinogen, ICAM-1, and iC3B.

A furanyl thiazolidinone compound that binds CD11b αA/αI domain in a reversible manner and stabilizes αA in a high-affinity binding conformation toward known CD11b/CD18 (αMβ2; CR3; Mac-1) ligands, fibrinogen, ICAM-1, and iC3B. Reported to be superior to IMB-10 (Cat. No. 407271) in enhancing Mac-1-mediated cell adhesion (EC50 = 4 vs. >50μM on fibrinogen surface). Effectively suppresses leukocyte recruitment in various inflammatory disease models involving mice, rats, and zebrafish embryos in vivo .
TRUSTED_SUSTAINABILITY

Specifications

Color Red-brown
Description 95% by HPLC
Molecular Formula C22H15NO4S2
Formula Weight 421.5g/mol
Solubility DMSO
Content And Storage Protect from light
Form Solid
Quantity 25 mg
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