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MilliporeSigma™ Calbiochem™ LFM-A13

Catalog No. 4353005MG Shop All MilliporeSigma Products
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43-530-05MG 5 mg
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Description

A potent, cell-permeable, reversible, substrate competitive, and specific inhibitor of Bruton's Tyrosine Kinase (BTK; IC50 = 17.2μM for human BTK

A potent, cell-permeable, reversible, substrate competitive, and specific inhibitor of Bruton’s Tyrosine Kinase (BTK; IC50 = 17.2μM for human BTK in vitro and IC50 = 2.5μM for recombinant BTK). Also inhibits Polo-like kinase in an ATP-competitive manner (IC50 = 10μM and 61μM for Plx1 and Plk3, respectively), and displays antitumor properties. Does not affect the enzymatic activity of other protein tyrosine kinases, including EGFR, HCK, IRK JAK1, and JAK3 even at concentrations of 278μM. Enhances the chemosensitivity of BTK-positive B-lineage leukemia cells to ceramide- and vincristine-induced apoptosis.
TRUSTED_SUSTAINABILITY

Specifications

Color Light Brown
Description 97% by HPLC
Target Proteins Human Bruton's Tyrosine Kinase (BTK)
CAS 62004-35-7
Molecular Formula C11H8Br2N2O2
Formula Weight 360g/mol
Solubility DMSO
Content And Storage Protect from light
Form Solid
Quantity 5 mg
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