MilliporeSigma™ Calbiochem™ Lovastatin

Catalog No.	Quantity
43-818-525MG	25 mg

Catalog No. 43-818-525MG Supplier MilliporeSigma™ Supplier No. 43818525MG

Description

Lovastatin, CAS 75330-75-5, is an anti-hypercholesterolemic agent that inhibits the activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase.

An anti-hypercholesterolemic agent that inhibits the activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. Has been shown to block a series of biological events including: the activation of p21 ^ras by insulin in 3T3-L1 fibroblasts and 3T3-L1 adipocytes; the farnesylation of p21 ^ras , which decreases the pool of intracellular Ras available for subsequent activation by growth factors (including insulin); and N- ras -induced neuronal differentiation. Causes cell cycle arrest in the late G₁ phase through inhibition of proteasome. Has recently been shown to inhibit the stimulation of MAP kinase by insulin in HIRcB cells and to block the transcription of type-I SCR gene in THP-1-derived macrophages. Also blocks PDGF receptor tyrosine phosphorylation and MAP kinase activation by PDGF. This product requires activation for use in cell synchronization studies and in cell-free assay systems for HMG-CoA studies.

Specifications

• Color: White to Off-white
• Description: 95% by HPLC
• Target Proteins: Activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase
• CAS: 75330-75-5
• Molecular Formula: C₂₄H₃₆O₅
• Formula Weight: 404.5g/mol
• Solubility: DMSO or EtOH
• Content And Storage: Protect from light
• Form: Powder
• Quantity: 25 mg