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MilliporeSigma™ Calbiochem™ MAT2A Inhibitor II, FIDAS-5

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10mg

Catalog No. 50-417-30001

Supplier: MilliporeSigma™ 5041730001

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Description

A cell-permeable fluorinated N,N-dialkylaminostilbene (FIDAS) analogue of FIDAS-3 (Cat

A cell-permeable fluorinated N,N-dialkylaminostilbene (FIDAS) analogue of FIDAS-3 (Cat. No. 681677) that competes against SAM for MAT2A binding and is >2-fold more potent than FIDAS-3 in inhibiting MAT2A-catalyzed SAM synthesis both in cell-free assays (IC50 = 2.1μM) and in LS174T colorectal cancer (CRC) cultures (3μM). FIDAS-5 at 3μM is shown to completely inhibit the proliferation of LS174T for up to 7 d in vitro and effectively suppress HT29 CRC tumor expansion in mice in vivo (20mg/kg/day p.o.).
TRUSTED_SUSTAINABILITY

Specifications

Color Yellow
Description 98% by HPLC
Target Proteins MAT2A
Molecular Formula C15H13ClFN
Solubility DMSO
Content And Storage Protect from light
Form Semi-solid
Quantity 10 mg
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