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  6. 44413025MG

MilliporeSigma™ Calbiochem™ Mcl-1 Inhibitor, MIM1

Catalog No. 44413025MG Shop All MilliporeSigma Products
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25mg

Description

A cell-permeable thiazolyliminopyrogallol that selectively neutralizes Mcl-1, but not Bcl-XL , antiapoptotic activity by directly targeting Mcl-1 BH3-binding site, effectively competing against Bid BH3 sequence for Mcl-1 binding (IC50

A cell-permeable thiazolyliminopyrogallol that selectively neutralizes Mcl-1, but not Bcl-XL, antiapoptotic activity by directly targeting Mcl-1 BH3-binding site, effectively competing against Bid BH3 sequence for Mcl-1 binding (IC50 = 4.8μM). Shown to induce caspase 3/7 activation and cell death in Mcl-1-, but not Bcl-XL-, dependent B-ALL cultures (6% vs. 82% survival, respectively; 10μM). In comparison, ABT-737 (Cat. No. 197333) affects only Bcl-XL-, but not Mcl-1-, dependent B-ALL cells. Neither MIM1 nor ABT-737 significantly affects the survival of wild-type or Bax-/- Bak-/- MEF.
TRUSTED_SUSTAINABILITY

Specifications

Color Yellow
Description 97% by HPLC
Target Proteins Mcl-1
Molecular Formula C17H21N3O3S
Formula Weight 347.4g/mol
Solubility DMSO
Content And Storage Protect from light
Form Powder
Quantity 25 mg
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