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MilliporeSigma™ Calbiochem™ Methotrexate

Inhibits thymidylate synthetase, is a nonselective de novo purine synthesis inhibitor, and has a significant toxicity profile including hepatotoxicity, pneumonitis, and bone marrow suppress

Manufacturer:  MilliporeSigma™ 454126100MG

Catalog No. 45-412-6100MG


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Description

Description

Inhibits thymidylate synthetase, is a nonselective de novo purine synthesis inhibitor, and has a significant toxicity profile including hepatotoxicity, pneumonitis, and bone marrow suppression. Potent folic acid antagonist. Induces apoptosis in HL-60 human leukemia cells. Also useful as an antitumor agent.
Specifications

Specifications

98% by HPLC
Protect from Light
59-05-2
508.5g/mol
Yellow solid
100mg
C20H22N8O5·3H2O
DMSO
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