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MilliporeSigma™ Calbiochem™ Methysergide Maleate

An antagonist of the 5-HT2B (pki

Manufacturer:  MilliporeSigma™ 5.06419.0001

Catalog No. 50-641-90001

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An antagonist of the 5-HT2B (pki = 8.0-9.4) and 5-HT2C (pki = 8.6-9.1) receptor. At the 5-HT1A and some other 5-HT receptors it serves as a partial agonist. It is known to have partial agonist effects on other 5-HT receptors as well. In neuronal and platelet culture, Methysergide blocks serotonin action with an IC50 = 18μM. Originally developed in the 1960′s as a migraine/cluster headache treatment, but discontinued due to significant physiological and pyschotropic side effects. Methysergide is still actively used in research as a 5-HT2 receptor antagonist in both in vivo and in vitro experiments.


99% by HPLC
Protect from Light
Off-white solid
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