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MilliporeSigma™ Calbiochem™ Methysergide Maleate

Catalog No. 5064190001 Shop All MilliporeSigma Products
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10mg

Description

An antagonist of the 5-HT2B (pki

An antagonist of the 5-HT2B (pki = 8.0-9.4) and 5-HT2C (pki = 8.6-9.1) receptor. At the 5-HT1A and some other 5-HT receptors it serves as a partial agonist. It is known to have partial agonist effects on other 5-HT receptors as well. In neuronal and platelet culture, Methysergide blocks serotonin action with an IC50 = 18μM. Originally developed in the 1960′s as a migraine/cluster headache treatment, but discontinued due to significant physiological and pyschotropic side effects. Methysergide is still actively used in research as a 5-HT2 receptor antagonist in both in vivo and in vitro experiments.
TRUSTED_SUSTAINABILITY

Specifications

Color Off-white
Description 99% by HPLC
Target Proteins 5-HT
Molecular Formula C21H27N3O2·C4H4O4
Formula Weight 469.54g/mol
Solubility H2O
Content And Storage Protect from light
Form Solid
Quantity 10 mg
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