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MilliporeSigma™ Calbiochem™ Midkine Inhibitor, iMDK

Catalog No. 5080520001 Shop All MilliporeSigma Products
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50-805-20001 10 mg
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Catalog No. 50-805-20001 Supplier MilliporeSigma™ Supplier No. 5080520001
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Description

A cell-permeable imidazothiazolyl-chromenone compound that reduces cellular midkine/MDK protein level in H441 lung adenocarcinoma cells in a dose-dependent manner (by >90% in 48 h at 25nM) via a yet unidentified mechanism

A cell-permeable imidazothiazolyl-chromenone compound that reduces cellular midkine/MDK protein level in H441 lung adenocarcinoma cells in a dose-dependent manner (by >90% in 48 h at 25nM) via a yet unidentified mechanism. Shown to inhibit the viability of MDK-positive HEK293, H441, and H520 cells (by ≥60% at 500nM in 48 h), but not MDK-negative NHLF or HEK293 (by <15% at 500nM in 48 h), via apoptosis induction as a result of PI 3-K/AKT signaling inhibition. Intraperitoneal injection is reported to be efficacious in retarding H441 tumor expansion in mice (9mg/kg; 3X to 5X per wk) in vivo .
TRUSTED_SUSTAINABILITY

Specifications

Color Off-white
Description 98% by HPLC
Target Proteins Midkine
Molecular Formula C21H13FN2O2S
Solubility DMSO
Content And Storage Protect from light
Form Solid
Quantity 10 mg
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