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MilliporeSigma™ Calbiochem™ Mitochondrial Content Inducer, BRD6897

Catalog No. 5059840001 Shop All MilliporeSigma Products
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Quantity:
25 mg

Catalog No. 50-598-40001

Supplier: MilliporeSigma™ 5059840001

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Description

A cell-permeable indolylphenylthienopyrimidinone compound that increases mitochondrial content without affecting the cell size (∽10μM). Reduces mitochondrial protein turnover without affecting any known transcriptional programs of mitochondrial biogenesis.

A cell-permeable indolylphenylthienopyrimidinone compound that increases mitochondrial content without affecting the cell size (∽10μM). Reduces mitochondrial protein turnover without affecting any known transcriptional programs of mitochondrial biogenesis. Reversibly increases uncoupled respiration in non-dividing cells (∽50% increase in 3T3-L1 and HUVEC at 10μM), but appears to be toxic to dividing cells. Shown to increase the expression of mitochondrial DNA encoded oxidative phosphorylation (OxPhos) genes without affecting nuclear DNA encoded OxPhos gene expression.
TRUSTED_SUSTAINABILITY

Specifications

Color Off-white
Description 98% by HPLC
Molecular Formula C25H21N3O2S2
Solubility DMSO
Content And Storage Protect from light
Form Powder
Quantity 25 mg
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